- Email:
- Phone:
- Add:
Zebrafish Pharmacokinetic Analysis Service
Zebrafish serve as model organisms for studying the absorption, distribution, metabolism, and excretion of drugs in living organisms. BioVenic possesses extensive experience and reliable technical support in providing this service.
The preclinical testing phase of a drug involves determining its optimal dosage and evaluating its efficacy and safety. Additionally, pharmacokinetic analysis is necessary to study the drug's metabolic pathways, its breakdown products, and its interactions with other medications. By quantitatively examining how a drug behaves in the body, pharmacokinetics helps to clarify the drug's mechanism of action and to develop an optimal treatment regimen. Zebrafish serve as a valuable experimental model due to their unique biological characteristics and ease of use, making them one of the best options for pharmacokinetic analysis.
Fig.1 Advantages of zebrafish as a model organism. (Garg & Geurten, 2024)
Zebrafish, as common research models for aquatic organisms, have many advantages. Zebrafish are efficient models for drug metabolism and toxicity studies due to their rapid development, small size, and low cost, enabling large-scale screening and quick data collection. Their high genomic and physiological similarity to humans ensure pharmacokinetic relevance. The transparency of their embryos allows real-time observation of drug distribution and metabolism using fluorescent labeling. Additionally, their flexible drug administration routes, including immersion and precise injection, make them a versatile tool for pharmacological research.
Relatively Short Lifespan
Enriched Genomics Information
High Biological Relevance
Easy to Track and Image
It is the study of the absorption, distribution, metabolism and excretion (ADME) of drugs with zebrafish as models. This adds to our understanding of how drugs work, their efficacy and safety, and how to best use them by quantifying how they behave in the body.
Unveil Drug Metabolic Mechanism
Pharmacokinetic analysis assists in elucidating the metabolic pathways of drugs and the metabolites' nature, which is essential for understanding the metabolic stability of drugs and whether they interact with other substances.
Evaluate Efficacy and Safety of Drugs
It helps to interpret the key parameters of drug action in the body, thus predicting the efficacy and potential risks of the drug and minimizing toxic side effects.
Determine Optimal Doses of Drugs
By calculating drugs’ concentration variation in the body, it determines the appropriate dose and frequency of administration to avoid side effects caused by too high or too low doses.
Optimize Route of Administration
Various administration modes exist, and pharmacokinetics analysis contributes to understanding how these different modes affect drug absorption and bioavailability. It helps in selecting the most effective route of administration.
Using zebrafish as experimental models, BioVenic offers several services related to pharmacokinetic analysis, including but not limited to the methods listed below. In addition, we also provide customized services on an as-needed basis.
Absorption Analysis
Distribution Analysis
Excretion Analysis
Drug-drug Interaction (DDI) Evaluation
Toxicity and Safety Evaluation
Professional Team
Customized Services
Innovative Technology
Efficient Services
Relying on cutting-edge technology and rich research experience, BioVenic provides professional aquatic biology research solutions for researchers around the world. Don't hesitate to contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.