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Metabolic Disease Models
Metabolic diseases are characterized by obesity, hyperglycemia, hypertension, and dyslipidemia. As a multifactorial disease, establishing appropriate experimental animal models to simulate the disease state in humans is essential to address the difficulties of assessing human metabolic pathophysiology. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal metabolic disease models in research.
Metabolic complex diseases have become a public health problem worldwide due to their increasing incidence, and it is challenging to select an appropriate experimental model that best represents human metabolic pathophysiology. The aquatic Animal Metabolic Disease model uses aquatic organisms to study human metabolic diseases such as diabetes, obesity, and fatty liver disease. Aquatic metabolic disease models are used to uncover the complex molecular and cellular mechanisms behind metabolic disorders, identify potential drug candidates targeting specific metabolic pathways, evaluate the effectiveness of new treatments, and study the impact of environmental factors such as diet and pollutants on metabolic health and disease development.
Fig. 1 Zebrafish as a model for metabolic disease. (Angom, R.S. & Nakka, N.M.R.; 2024)
Aquatic animal models are uniquely positioned to complement mammalian models and provide unique insights into disease mechanisms and potential therapies. For example, the genetic conservation between zebrafish and humans, its high fertility, and transparent embryos enable large-scale genetic and drug screening studies. Zebrafish possess a simplified cardiovascular system similar to that of mammals, making them particularly suitable for modeling aspects of heart development, function, and disease.
Aquatic animal metabolic disease models provide valuable tools for advancing the understanding of metabolic disorders and developing new therapies and have become an important part of biomedical research. They contribute to a more complete understanding of metabolic diseases and accelerate the development of effective therapies. BioVenic offers a range of aquatic animal metabolic disease models, including but not limited to the following.
Diabetes Model
Diabetic zebrafish are used to study glucose homeostasis, insulin resistance, and complications of diabetes.BioVenic constructs diabetes models through genetic modification or chemical induction.
Obesity Model
BioVenic constructs obesity models through genetic modification or gene manipulation to study the mechanisms of fat accumulation and the effects of obesity on other organ systems.
Fatty Liver Model
BioVenic establishes the fatty live model for the study of non-alcoholic fatty liver disease and its development, including liver structure and liver function.
Metabolic Syndrome Model
Aquatic animal models offered by BioVenic can be used to study the interactions of various metabolic parameters in metabolic syndromes, such as glucose metabolism, lipid metabolism, and blood pressure.
Professional Team
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Aquatic animals, such as zebrafish, have become well-regarded and versatile model species for studying metabolic diseases, offering unique advantages for basic research and drug discovery. In addition, using aquatic models can result in significant cost savings compared to mammalian models. Our experienced biology and aquaculture experts team provides comprehensive support throughout the modeling process, from initial consultation and design to implementation and monitoring. If you are seeking a reliable partner to support your aquatic animal research projects, please contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.