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Aquatic Animal Cardiac Toxicity Assay Service
Aquatic animal cardiac toxicity assay is commonly used to assess the potential harmful effects of drugs or chemical substances on the heart in aquatic animal. At BioVenic, our service support is dedicated to safeguarding the integrity of aquatic ecosystems, ensuring your projects compliance with all relevant laws and regulations.
Cardiac toxicity assay is primarily designed for use on aquatic species, including fish, crustacean, and shellfish. By conducting a thorough analysis of cardiac function, heart rhythm changes, and physiological responses in various aquatic species, along with the use of advanced electrophysiological monitoring technology, biomarker detection, and imaging technology, this test offers clients a comprehensive cardiotoxicity assessment. The primary objective of this assessment is to help clients identify potential toxicity risks and ensure the safety of their products or the environment.
Fig. 1 Examine the cardiotoxic effects of aluminum exposure in Amazonian fish. (Cantanhêde, et al., 2022)
Cardiotoxicity assays for aquatic organisms are critical in drug screening and development. By identifying potential cardiac risks at an early stage, these tests help ensure the safety of drugs before clinical trials. In addition, the test can be used to assess the impact of contaminants in aquatic systems on the environment, aquaculture, and the growth of marine species, among other things, to prevent them from negatively affecting aquatic ecosystems.
Drug Development
Physiology and Behavior
Aquaculture Promotion
Environment Resaerch
BioVenic provides various molecular biology assays and toxicity assessment protocols for fish, crustaceans, amphibians, and other aquatic invertebrates. Additionally, the company offers physiological assays and advanced imaging technologies for electrophysiological studies to monitor action potentials and their changes in the fish heart, and to track cardiac changes induced by drugs or contaminants.
Cardiac Muscle Tissue Analysis
For this analysis, we offer a range of techniques, including immunohistochemical staining, Masson trichrome staining, and other methods, to observe the morphological changes to cardiac muscle tissue in response to toxicity exposure, as well as relevant physiological and biochemical indicators.
Cardiac Function Testing
Here we have hemodynamic monitoring or ultrasound imaging techniques that can assess cardiac function in aquatic organisms by indicators such as myocardial contractility and pumping efficiency, which can be used to study the effects of drugs on potential heart failure or cardiac dysfunction.
Cardiac Development Assay
Using fluorescence microscopy or image analysis software, the development processes of the heart and functional phenotypes of the heart will be monitored using an ideal cardiac development model, such as zebrafish and ricefield eel. Compound effects on cardiac development will be assessed as well.
Gene Expression Analysis
The technique is used to assist you in analyzing the mechanism of cardiotoxic effects by detecting the expression levels of key genes in cardiac tissues, assisting in the identification of key gene pathways that cause cardiac damage.
Professional Team
Customized Services
Innovative Technology
Efficient Services
BioVenic offers cardiotoxicity testing services to evaluate the impacts of chemicals, drugs, and pollutants on aquatic ecosystems by analyzing the cardiac functions of various species. For accurate and timely results that support your research needs, please contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.