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Tumor Models
Aquatic animal tumor models are an important tool for cancer research, helping to understand tumor biology, drug efficacy, and disease progression. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal tumor models in cancer research. Our team of experienced biology and aquaculture experts provides comprehensive support throughout the tumor-modeling process, from initial consultation and design to implementation and monitoring.
Fig. 1 Optically transparent zebrafish can be used in therapeutic development pipelines for various human cancers. (Yan C.; et al. 2019)
Aquatic animal tumor models use marine species' unique physiological and genetic characteristics to study tumor occurrence and development. They also present ethical advantages over mammalian models, allowing in vivo studies with reduced regulatory burdens. In addition, these models enable researchers to conduct longitudinal studies of cancer evolution and therapy response, leading to a deeper understanding of tumor heterogeneity.
| Species | Advantages | Applications |
| Zebrafish (Danio rerio) |
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| Medaka (Oryzias latipes) |
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BioVenic focuses on building aquatic animal tumor models and provides related preclinical drug development services, including but not limited to the following.
Target Identification and Verification
BioVenic creates aquatic animal models that express oncogenes or carry tumor-suppressor gene mutations to simulate specific human cancers for use in vivo to assess the effects of target gene function and regulation of their activity.
Drug Discovery and Screening
Aquatic animal embryos and larvae are ideal for high-throughput anti-tumor drug screening. BioVenic' real-time imaging technology directly visualizes drugs' effects on tumor growth, angiogenesis, and metastasis.
Drug Optimization and Development
BioVenic evaluates the ADME, drug formulation, and administration methods in aquatic animal models and optimizes therapeutic strategies. Toxicity studies also identify potential adverse effects and guide dose selection.
Preclinical Validation
Evaluate the efficacy of drug candidates in aquatic animal tumor models, conduct mechanism studies, elucidate the molecular mechanisms of drug action, and gain insight into how drugs affect tumor cells and the surrounding microenvironment.
BioVenic has advanced imaging, molecular, and genetic integrated technology, which enhances aquatic models' ability to simulate human cancer and thus paves the way for new therapeutic strategies. These technologies facilitate a better understanding of tumor biology, the development of therapies, and the evaluation of drug efficacy.
Sequencing and Genomic Analysis
Imaging Technologies
Professional Team
Customized Services
Innovative Technology
Efficient Services
Aquatic animal tumor models are invaluable for revealing the complexity of cancer, ultimately helping provide better diagnostic and therapy options. As technology continues innovating and refining, aquatic models will play an increasingly important role in cancer research, providing unique insights that bridge the gap between basic science and final applications. If you are seeking a reliable partner to support your aquatic animal research projects, please contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.
