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Genetic Disease Models
Genetic diseases are caused by abnormalities in an individual's genetic material, including various diseases with varying severity and inheritance. Many genetic disease models are being developed and used in aquatic animals. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal genetic disease models in research.
Genetic abnormalities include single gene mutations and chromosomal abnormalities that affect the function of individual genes or disrupt larger segments of the genome. Genetic diseases are mainly divided into monogenic diseases, chromosomal abnormalities, multifactorial genetic diseases, and mitochondrial diseases. The genetic disease model of aquatic animals is based on the bio-system of marine animals, aiming to replicate human genetic diseases and reveal the genetic pathways of pathology, providing valuable insights into genetics, disease mechanisms, and potential therapies, especially human genetic diseases with similar genetic characteristics or molecular mechanisms to aquatic species.
Fig. 1 High-throughput screening in vivo zebrafish is beneficial for discovering novel or retargeting drugs to treat rare genetic diseases. (Crouzier, L.; et al.; 2021)
Using aquatic genetic disease models to study human genetic diseases has unique advantages that complement mammalian models. These models utilize species such as zebrafish, medaka, and African clawed frogs, fully utilizing their advantages.
Aquatic genetic disease models help to understand disease mechanisms, identify drug targets, and develop new therapies. They are valuable tools for studying gene function, developmental processes, and disease pathogenesis. Although they cannot perfectly replicate the human condition, they provide powerful platforms for preclinical research and drug discovery. BioVenic offers a range of aquatic animal genetic disease models, including but not limited to the following.
Muscular Dystrophy
Zebrafish lack muscle dystrophin, a protein crucial for muscle function, and exhibit muscle degeneration similar to human Duchenne muscular dystrophy (DMD).
Cystic Fibrosis
Embryos injected with mRNA encoding the mutated cystic fibrosis transmembrane conductance regulator (CFTR) are used to mimic certain features of human cystic fibrosis.
Transgenic medaka expressing human oncogenes can serve as a melanoma model for studying tumor formation processes and identifying potential therapeutic targets.
Transgenic zebrafish expressing human amyloid precursor (APP) mutations associated with Alzheimer's disease exhibit amyloid plaque formation and cognitive deficits.
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The combination of genetic tractability, optical clarity, and cost-effectiveness of aquatic animals makes them an important component of biomedical research, bridging the gap between basic science and clinical applications. The aquatic animal genetic disease models provided by BioVenic accelerate the development of personalized medical methods and help to gain a deeper understanding of human genetic diseases. Don't hesitate to contact us if you are seeking a reliable partner to support your aquatic animal research projects.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.