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Aquatic Animal Neurotoxicity Assay Service
Neurotoxicity assay evaluates the potential neurotoxic effects of compounds, environmental contaminants or biological agents. BioVenic is committed to the conservation of providing scientific research services targeting aquatic animals. We adhere to the principles of scientific rigor and ethical compliance, and we are dedicated to contributing to global aquatic conservation efforts and providing a scientific basis for ecological balance and sustainable development.
Neurotoxicity usually refers to toxic effects on the structure, function or development of the nervous system. Neurotoxicity assay is a valuable tool that can be used to study the effects of compounds on neuronal survival, synaptic function, electrophysiological properties and molecular signaling pathways. The high responsiveness of the nervous system of aquatic organisms to external chemicals makes them highly desirable biological models for toxicological studies.
Fig. 1 Conduct a meta-analysis on the neurotoxic effects of microplastics in aquatic animals. (Xiong, et al., 2023)
Neurotoxicity assay is primarily used to screen for potentially toxic compounds to ensure that new drugs, chemicals, or other products do not harm ecosystems or biological development before they are released to the market. The test is widely used in the fields of environmental toxicology, drug and chemical safety assessment, genotoxicity studies, and neurodegenerative disease research, helping to assess the effects of pollutants and chemicals on aquatic ecosystems and their organisms, and providing an important basis for environmental protection and public health.
Species and Genetics
Drug Development
Environment and Ecology
Physiology and Behavior
BioVenic provides research and evaluation including, but not limited to, aquatic organisms such as zebrafish and Xenopus laevis toad as models for a variety of metrics such as embryonic mortality and hatchability, morphological malformations, and molecular toxicity markers. At BioVenic, we offer advanced neurotoxicity assay services to ensure the safety and sustainability of aquatic ecosystems. Our cutting-edge assays assess the impact of environmental pollutants, chemicals, and new substances on the development of aquatic species, from embryos to juvenile stages.
Neurochemical Assay
Neurobiochemical-related tests are available with abundant aquatic animals regarded as ideal models, including tiger puffer, such as acetylcholinesterase activity, which is utilized to assess the effects of pollutants on the cholinergic system. In addition, neurotransmitter levels can be measured to assess whether chemicals affect nerve signaling.
Behavioral Assay
The assessment of changes in locomotor patterns, external stimuli to detect neurological responses, and aquatic adaptations was facilitated by the utilization of swimming behavior analysis, startle response testing, anxiety and exploratory behavior.
Neurodevelopmental Assay
The phenomena of neuronal differentiation, axon growth, and synapse formation were observed through the utilization of fluorescence microscopy and confocal microscopy. Moreover, 3D morphological analysis was performed using deep learning or machine learning techniques.
Neural Signal Detection
Multi-electrode arrays (MEAs) have been used to record neuronal firing patterns and assess the effects of chemicals on the neural activity of aquatic organisms, or patch-clamps have been used to study the function of ion channels and detect changes in neural signaling.
Professional Team
Customized Services
Innovative Technology
Efficient Services
BioVenic is committed to promoting the development of aquatic bioscience research, providing high-quality data, innovative technical solutions and accurate experimental analysis to help researchers explore the mysteries of aquatic ecosystems. Contact us for a tailor-made, professional service, a rigorous scientific approach and a wide range of innovative technical solutions.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.