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Cardiovascular Disease Models
The cardiovascular disease (CVD) model in aquatic animals provides valuable insights into disease mechanisms, drug discovery, and the development of new therapies. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal cardiovascular disease models in preclinical research.
CVD includes a range of diseases that affect the heart and blood vessels and is the leading cause of death worldwide. CVDs are caused by various factors, such as genetics, lifestyle choices, and environmental influences. Combined with non-invasive high-resolution imaging and phenotype-based screening, simple genetic manipulation provides new insights into molecular pathways that coordinate cardiac development.
Fig. 1 Zebrafish disease models for research on heart-related diseases. (Giardoglou, P.; & Beis, D.; 2019)
Due to the conservation of genes and regulatory pathways, as well as the similarity in heart rate and cardiac morphology and function, aquatic animals such as zebrafish can reproduce human cardiac pathophysiology.
The genetic conservation between aquatic animals and humans, as well as their high reproductive capacity and transparent embryos, make large-scale genetic and drug screening research possible. BioVenic offers a range of aquatic animal cardiovascular disease models and related technologies.
There are many types of cardiovascular-related diseases, and BioVenic offers a variety of aquatic animal models for simulating cardiovascular disease in humans, including but not limited to the following
Heart Failure
Aquatic animals have a strong ability to regenerate their myocardium after severe injury. Aquatic animals show promising prospects in heart failure research.
Cardiomyopathy
The aquatic animal dilated cardiomyopathy (DCM) model is beneficial for systematically elucidating the key genetic basis and molecular mechanisms of human DCM.
Cardiac Rhythm Disorders
Based on multiple gene screenings, aquatic animals produce mutants similar to arrhythmia, which can be applied to arrhythmia research.
Establishing a cardiovascular disease model in aquatic animals involves a series of technologies, and the specific methods depend on the target disease and research question.
BioVenic offers a variety of genetic manipulation technologies, including microinjection, Tol2 transposon system, Cre-Lox recombination, and gene expression analysis.
Pharmacological Induction
BioVenic induced aquatic animal disease models by drug administration or diet control and plotted drug dose-response curves for pharmacokinetic and pharmacodynamic analysis.
Surgical Intervention
BioVenic also constructs cardiovascular disease by methods of surgery, including cardiac ablation, blood vessel occlusion, and transplantation of cells or tissues.
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With the latest developments in next-generation sequencing (NGS) and the demand for personalized treatments, aquatic animals are increasingly being used to reveal potential connections between genotypes and phenotypes of numerous human diseases. By combining various advanced technologies, the aquatic animal cardiovascular disease model provided by BioVenic is of great significance for studying the mechanisms of human cardiovascular disease and developing new treatment strategies. If you are seeking a reliable partner to support your aquatic animal research projects, please contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.