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Zebrafish Biological Efficacy Evaluation Service
Zebrafish biological efficacy evaluation involves using zebrafish as a model organism to evaluate the effects of drugs on living organisms. BioVenic primarily offers various customized biological efficacy evaluations based on zebrafish.
Biological efficacy evaluations are mainly used to validate and quantify the effects of drugs on organisms and specific targets and ensure their efficacy and safety. It helps to identify candidate molecules and analyze the effects of candidate molecules on the organism at the molecular level.
Fig. 1 Zebrafish applications in skin biology. (Russo, et al., 2022)
Zebrafish are model organisms with unique advantages in biological efficacy evaluation. They have low feeding costs and an extremely short life cycle, which can greatly shorten the duration of experiments. About 70% of the genes in their genome are homologous to humans, which is convenient to operate in gene editing. Zebrafish have similar organ systems and mechanisms for absorbing and metabolizing drugs as humans, which is conducive to research on the treatment of related diseases. Meanwhile, due to the transparency of zebrafish embryos, they are very suitable for fluorescent labeling and in vivo imaging to directly observe physiological phenomena such as blood vessel growth and cell migration.
Relatively Short Lifespan
Enriched Genomics Information
High Biological Relevance
Easy to Track and Image
As an efficient and cost-effective model organism, biological efficacy evaluation services for zebrafish are varied, and BioVenic offers fully customized and individualized services that include the following.
| Methods | Details |
| Morphological Analysis | By employing high-resolution imaging and quantitative analysis, phenotypic alterations are monitored, such as body length, somite formation, organ size, edema, skeletal structure, and vascular development. |
| Behavior Assessment | Zebrafish behavioral assessment provides an integrative approach to evaluate compound effects on locomotion, learning and memory, social interaction, and stress-related responses. BioVenic provides different analyses including the following. |
| Physiology Evaluation | Zebrafish disease models or physiological abnormalities are established to test the effects of drugs, genes, or external factors, and bio-efficacy effects are assessed by changes in physiologically relevant indices. |
| Staining Analysis Service | We provide comprehensive zebrafish staining services for cartilage, bone, apoptosis, and specific cell types like neutrophils. Additionally, we offer a wide range of related antibody kits for immunohistochemistry and functional detection, such as ROS assays. |
Disease modeling in zebrafish provides a powerful in vivo platform to simulate human pathological conditions, enabling the evaluation of drug efficacy and mechanism of action in a whole-organism context. BioVenic offers disease modeling services for aquatic organisms, and some of them are shown below. These models allow for high-throughput screening and phenotypic analysis, facilitating the identification of therapeutic candidates and the validation of target-specific responses in a cost-effective and time-efficient manner.
Professional Team
Customized Services
Innovative Technology
Efficient Services
In the field of aquatic biology research, BioVenic provides various services from experimental design to data analysis based on deep expertise and innovative technologies. We are committed to helping make breakthroughs in research with the most rigorous attitude and the most efficient way of working. Don't hesitate to contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.