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Aquatic Animal Models Development
Aquatic animal models utilize aquatic organisms to study human biology and diseases. Aquatic animal models have unique advantages that complement mammalian models, driving progress in various research fields. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal models in medical research.
The usefulness of aquatic animals as models for disease research is based on general characteristics shared by many species and characteristics unique to individual species or groups of related species. Some general characteristics of many species make them valuable in pathology and toxicology studies, including high fertility, in vitro fertilization, transparent eggs, and relatively short reproductive times. For toxicological studies, aquatic animals have easy access to aquatic compounds through their gills and the relatively large epithelial surface area of their skin, and thanks to poikilothermic physiology, the effect of body temperature on the disease process can be studied, a huge advantage shared by most aquatic organisms.
Fig. 1 The zebrafish's ability to simulate disease and cure it. (Patton EE, et al.; 2021)
Due to the conservation of genes and regulatory pathways, as well as the similarity in heart rate and cardiac morphology and function, aquatic animals such as zebrafish can reproduce human cardiac pathophysiology.
Aquatic animals have multiple applications in human disease research, covering various stages from basic understanding to treatment development. Harnessing the unique strengths of aquatic animals can gain valuable insights into human diseases and accelerate the development of new, more effective therapies.
Understanding Disease Mechanisms
Drug Discovery and Development
Therapy Development and Evaluation
Aquatic invertebrates and fish are valuable model organisms because they have specific physical characteristics, such as mega axons, and provide an evolutionary perspective on the structure and function of higher vertebrate systems. Hence, aquatic animal models are used in biological processes and diseases. BioVenic offers a range of aquatic animal models, including but not limited to the following.
Aquatic animal tumor models simulate tumor development and high-throughput test the effectiveness or toxicity of anticancer drugs.
Aquatic animal neurological disorder models study human brain development, functional mechanisms, and neurological diseases.
Aquatic animal metabolic disease models understand the metabolic mechanisms by studying embryonic development, organogenesis, and tissue regeneration.
The aquatic animal inflammatory disease model helps to elucidate the complex molecular and cellular mechanisms driving inflammatory diseases.
Aquatic animal cardiovascular disease models study heart development and function, as well as simulate heart defects and other cardiovascular diseases.
Aquatic animal genetic disease models investigate the molecular basis of hereditary conditions and test potential gene therapies. These models are crucial for understanding gene function, validating disease-causing mutations, and evaluating innovative treatment strategies for various genetic disorders.
Musculoskeletal Disease Models
Aquatic animal musculoskeletal disease models simulate human bone and muscle disorders to study development and regeneration. These models facilitate research on skeletal development, muscle function, and the screening of therapeutic compounds for conditions like osteoporosis and muscular dystrophy.
Aquatic animal auditory disease models investigate hearing loss and inner ear development. These models are particularly valuable for studying hair cell regeneration and screening ototoxic or protective compounds, providing insights into auditory function and potential treatments for hearing disorders.
Aquatic animal ophthalmic disease models recreate human eye conditions to study visual system development and pathology. These models enable research on retinal degeneration, lens regeneration, and the evaluation of therapeutic interventions for various ocular diseases.
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The study of aquatic animal diseases involves a variety of disciplines, such as physiology, pathology, toxicology, immunology, microbiology, embryology, molecular biology, and genetics. Based on the above-specialized team of experts, BioVenic provides aquatic animal models related to human diseases for the study of a variety of disease-related problems. If you are seeking a reliable partner to support your aquatic animal research projects, please contact us.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.