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Zebrafish Efficacy and Safety Evaluation Service for Food and Nutraceuticals
The Zebrafish (Danio rerio) model is rapidly becoming the essential vertebrate platform for early-stage efficacy and safety evaluation in the nutraceutical industry, offering a high-throughput, ethically sound alternative to conventional preclinical studies. BioVenic leverages state-of-the-art genetic and imaging technology, including transgenic fluorescent lines for real-time tracking of immune cells and lipid metabolism, and advanced gene editing systems for generating custom disease models that accurately mimic complex human conditions. This highly translational platform is designed to deliver biologically relevant data faster and more economically than conventional methods.
The adoption of the Zebrafish model marks a significant shift in food and nutraceutical R&D, offering the essential speed and predictive power of an in vivo system. As a whole-organism vertebrate, the Zebrafish shares over 80% gene homology with humans, possesses fully functioning organ systems, and exhibits rapid ex utero development, enabling comprehensive, mechanistic screening that delivers superior data quality compared to simple in vitro results. This model's utility is validated for assessing complex pathways, such as anti-obesity effects confirmed in specialized journals like Food & Function, and for initial toxicological screening that aligns with regulatory guidelines including US EPA's OPPTS 850.1075. BioVenic's platform is engineered to leverage these advantages, providing scientific substantiation for robust marketing claims and regulatory acceptance by rapidly de-risking novel ingredients.
Fig.1 Strategies for evaluating ingredients in aquaculture using zebrafish models.1,2
The intrinsic advantages of the Zebrafish model, combined with BioVenic's technological expertise, create powerful applications for ingredient developers seeking defensible, high-quality data. We empower clients to make data-driven decisions at the earliest phases of development.
BioVenic offers a modular suite of services targeting both the efficacy and safety profiles of ingredients using specialized Zebrafish models and cutting-edge analytical techniques. Our comprehensive approach is divided into Efficacy Screening and Safety Evaluation, delivering precise, actionable data to substantiate health claims and ensure ingredient purity.
| Service / Target | Technology & Process | Key Platform & Output |
| Targeted Metabolic & Anti-Obesity Efficacy | High-Fat Diet (HFD) models induce metabolic syndrome; precise quantification of lipid droplets via fluorescent dyes. | Direct in vivo measurement of anti-lipogenic or lipolytic activity, leveraging transgenic lines for visualization. |
| In Vivo Anti-Inflammatory Screening | Controlled immune response induction (e.g., tail fin amputation); real-time tracking of fluorescently labeled immune cells. | Quantification of leukocyte recruitment; results backed by qPCR analysis of pro-inflammatory genes (e.g., TNF-alpha). |
| Organ-Specific & Contaminant Toxicity | Compound exposure from 6 hours post-fertilization (hpf), followed by detailed histopathology and molecular analysis. | Targeting Nephrotoxicity and Hepatotoxicity; validated for screening key food contaminants like mycotoxins (citrinin/patulin and pharmaceutical residues. |
Professional Team
Customized Services
Innovative Technology
Efficient Services
Choosing BioVenic means partnering with a leader in translational aquatic research. We combine proven scientific methods - validated by specialized, peer-reviewed publications - with proprietary high-throughput capabilities to deliver actionable in vivo data. Our expertise mitigates preclinical risk and accelerates your time-to-market. Contact us and submit your requirements to receive a detailed quote and discover the speed of Zebrafish R&D.
Reference
Our products and services are for research use only and cannot be used for any clinical purposes.