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Inflammation Disease Models
Aquatic animals have multiple advantages that make them suitable for inflammatory disease research, such as easy genetic manipulation and suitable for high-throughput screening of anti-inflammatory drug candidates. BioVenic has advanced biotechnology that greatly facilitates the development and application of aquatic animal metabolic disease models in preclinical research.
Inflammation is a complex biological response to harmful stimuli, and dysregulation of inflammatory responses has been observed in various diseases. Abnormal and over-activated inflammation plays a crucial role in the pathogenesis of inflammatory diseases such as asthma, rheumatoid arthritis, and allergy and autoimmune diseases. Animal models of inflammation provide valuable insights into related disease mechanisms and potential therapies. Among them, bony fish have shown several advantages over other animals and can be used as an alternative to rodent experimental models. Notably, the swim bladder is an endocardial organ with an end-circulation that can easily inoculate with inflammatory agents and collect exudate to assess the cellular components and fluids that accumulate in inflammatory lesions.
Fig. 1 Schematic diagram of the commonly used zebrafish larva inflammation model. (Xie Y, et al.; 2021)
The development of aquatic animal models adds a complementary system to rodent models for high-throughput screening in vivo. The similarity of the immune system and inflammatory response of aquatic animals to that of mammals guarantees good translational value.
BioVenic offers a range of aquatic animal inflammation disease models, including but not limited to the following.
Aquatic inflammatory disease models can be constructed in a variety of ways. BioVenic provides animal model-building methods, including but not limited to the following.
Wounding-Induced Inflammation
BioVenic uses a caudal-fin excision model to study inflammatory responses and regenerative processes, including specific signaling pathways, leukocyte migration, and immune cell interactions. It is also used to screen natural compound libraries and drugs.
Chemical-Induced Inflammation
BioVenic uses different chemicals to induce aquatic animal models of inflammation, which can be targeted to simulate various types of inflammatory diseases.
Mutation-Induced Inflammation
Zebrafish lines carrying genetic mutations exhibit inflammatory phenotypes.
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The use of animal models is an important part of biomedical research and is crucial for the development of novel drugs. However, rodent systems have limitations such as high feeding and breeding costs, and they are not suitable for large-scale automated screening. The experienced biology and aquaculture expert team of BioVenic provides comprehensive support throughout the aquatic animal inflammation disease modeling process, from initial consultation and design to implementation and monitoring. Please contact us if you are seeking a reliable partner to support your aquatic animal research projects.
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