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Bioavailability Assay
Bioavailability assay, designed for assessing the absorption and accumulation of substances in aquatic organisms, evaluates how chemicals, pharmaceuticals, and environmental pollutants are taken up by aquatic species. This assay provides valuable data on the bioavailability of substances, helping to understand their potential impact on aquatic life. BioVenic offers specialized bioavailability assay services to support environmental risk assessments and regulatory compliance in aquatic ecosystems.
The bioavailability assay evaluates the absorption, distribution, and accumulation of chemicals in aquatic organisms, providing essential data on how substances interact with living systems. Often conducted using model species like zebrafish, this assay is crucial for understanding the environmental and toxicological risks posed by pharmaceuticals, agrochemicals, and pollutants. Recognized as a cornerstone in environmental toxicology, it helps predict the ecological impact of bioavailable contaminants. Recent advancements, such as nano-sensor technologies and imaging techniques, have enhanced the precision and efficiency of bioavailability assessments, supporting high-throughput screening and regulatory compliance in chemical safety evaluations.
Fig. 1 Workflow of Bioavailability Assay.
Bioavailability assays are essential tools for assessing the absorption and distribution of various substances in biological systems.
BioVenic has extensive expertise in performing bioavailability assays on aquatic organisms. We provide comprehensive services to evaluate the uptake and bioavailability of contaminants, including heavy metals and organic pollutants, using advanced methodologies and diverse aquatic models.
Embryo Incubation
Zebrafish embryos are carefully selected and incubated with the testing compound under controlled conditions. This ensures accurate assessment of the compound's bioavailability while minimizing external variables.
Experiment Monitoring
Throughout the incubation period, embryos are observed for any indications of toxicity or developmental abnormalities that may influence bioavailability results.
Sample Preparation
At the conclusion of the incubation, whole embryos or specific tissue sections are collected and lyophilized to preserve the samples for detailed chemical analysis.
Chemical Analysis
The lyophilized samples are analyzed using advanced techniques like Mass Spectrometry or Nuclear Magnetic Resonance (NMR) to detect and quantify the compound within the embryos.
Drug Content Calculation
The lyophilized samples are analyzed using advanced techniques like Mass Spectrometry or Nuclear Magnetic Resonance (NMR) to detect and quantify the compound within the embryos.
Data Analysis & Reporting
A thorough data analysis is conducted to compile a comprehensive report that includes key reproductive toxicity endpoints, detailed statistical evaluations, and insights into potential environmental and regulatory impacts.
Professional Team
Customized Services
Innovative Technology
Efficient Services
With a team of experienced analytical chemists and aquatic toxicology experts, BioVenic is dedicated to advancing research through efficient bioavailability testing. Our bioavailability assays for aquatic species offer reliable and comprehensive solutions to assess compound absorption and distribution in embryos. We are committed to delivering accurate, timely results tailored to your specific testing needs. For trusted support in bioavailability research and analysis, please contact us.
Our products and services are for research use only and cannot be used for any clinical purposes.
