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Recombinant Swine Protein S100 (S100A8), N-His
Product Overview
BioVenic's Recombinant Swine Protein S100 (S100A8), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 14.1 kDa. The purity is>95% (SDS-PAGE).
Specifications
Target Information
Swine protein S100A8 is a calcium-binding protein primarily expressed in granulocytes and monocytes, playing a significant role in regulating inflammatory processes and immune responses. It attracts neutrophils through chemotactic activity and binds to the receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4), mediating intracellular inflammatory signaling. In swine, research on S100A8 has shown that it is highly expressed in various inflammatory diseases, such as respiratory and gastrointestinal disorders. Additionally, S100A8 plays a crucial role in infectious diseases in pigs, for example, in Haemophilus parasuis (HPS) infection, where the expression of S100A8 is significantly upregulated, participating in the immune response.
Shipping and Storage
This product is shipped with dry ice. It is recommended to aliquote as needed and store at -80°C upon receipt. Reconstituted protein solution can be stored at 4°C for 1 week, at < -80°C for 12 months. Avoid repeated freezing and thawing.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL.Aliquote the reconstituted solution to minimise freeze-thaw cycles.