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Recombinant Staphylococcus aureus Alpha-hemolysin (hly), N-His
Product Overview
BioVenic's Recombinant Staphylococcus aureus Alpha-hemolysin (hly), N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 35.6 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Alpha-hemolysin (Hla) is a vital pore-forming cytotoxin secreted by Staphylococcus aureus. It is produced as a water-soluble monomer that binds to the ADAM10 receptor on host cell membranes, where it oligomerizes into a functional heptameric $\beta$-barrel pore. This pore causes rapid leakage of cytoplasmic contents and osmotic lysis. Hla plays a critical role in disrupting epithelial barriers and evading the host immune system, making it a primary target for neutralizing antibodies and vaccine development.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.