Recombinant Rabbit Metalloproteinase Inhibitor 1 (TIMP1), N-His

Rabbit Metalloproteinase Inhibitor 1 (TIMP1) is a vital protein that regulates the activity of matrix metalloproteinases (MMPs), a group of enzymes involved in the degradation of the extracellular matrix. TIMP1 forms one-to-one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. In rabbits, TIMP1 is crucial for maintaining tissue integrity and regulating processes like cell differentiation, migration, and apoptosis. It also acts as a growth factor, influencing cell proliferation and survival. Additionally, TIMP1 has been implicated in various pathological conditions, including inflammation and cancer, where it can modulate disease progression by controlling MMP activity. Its multifunctional nature makes TIMP1 an important target for research in tissue repair, cancer biology, and other related fields.