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Recombinant Rabbit Collagen Alpha-1(VIII) Chain (COL8A1), N-His
Product Overview
BioVenic's Recombinant Rabbit Collagen Alpha-1(VIII) Chain (COL8A1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 18.4 kDa. The purity is> 90%.
Specifications
Target Information
Rabbit Collagen Alpha-1(VIII) Chain (COL8A1) is a key component of type VIII collagen, which is a short-chain collagen found in the basement membrane of corneal endothelial cells and blood vessels. In rabbits, COL8A1 is essential for maintaining the integrity and structure of these tissues. It forms homotrimers or heterotrimers with alpha 2(VIII) collagen, contributing to the stability of the extracellular matrix. COL8A1 also plays a role in angiogenesis and artery remodeling, and its expression can influence the proliferation and migration of vascular smooth muscle cells. Additionally, COL8A1 has been implicated in the maintenance of vessel wall integrity, particularly in atherogenesis. Its presence in the Descemet's membrane of the cornea suggests a role in corneal health. These functions make COL8A1 an important target for studying vascular and ocular diseases.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.