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Recombinant Porphyromonas gingivalis Lys-gingipain W83 (kgp), C-His
Product Overview
BioVenic's Recombinant Porphyromonas gingivalis Lys-gingipain W83 (kgp), C-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 19.5 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
Lys-gingipain (Kgp) is a major extracellular cysteine protease and key virulence factor produced by Porphyromonas gingivalis. It specifically cleaves polypeptide chains at lysine residues. Kgp is essential for bacterial nutrition, as it degrades host proteins into smaller peptides for uptake. Furthermore, it subverts the host immune system by inactivating cytokines and complement factors, and contributes to tissue destruction by degrading collagen and fibrinogen. Its role in chronic periodontitis and potential links to systemic diseases like Alzheimer's make it a prime therapeutic target.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.