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Recombinant Plasmodium falciparum VAR2CSA Protein, N-His

Cat. No.VG3F267

Product TypeVeterinary Antigens

Size

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Product Overview

BioVenic's Recombinant Plasmodium falciparum VAR2CSA Protein, N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 24 kDa. The purity is>90% (SDS-PAGE).

Specifications

Type Recombinant Protein
Species Bacteria
Expression System E.coli Expression System
Purity >90% (SDS-PAGE)
Predicted Molecular Weight 24 kDa
Physical State Lyophilized
Formulation PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Target Information

VAR2CSA is a unique member of the PfEMP1 protein family specifically expressed by Plasmodium falciparum during pregnancy. Unlike other PfEMP1 variants, it does not bind CD36; instead, it mediates the sequestration of infected erythrocytes in the placenta by binding to Chondroitin Sulfate A (CSA) on syncytiotrophoblasts. This interaction leads to placental malaria, causing severe complications like low birth weight and maternal anemia. Due to its conserved function and critical role in pregnancy-associated pathology, VAR2CSA is a leading candidate for maternal malaria vaccines.

Protein Plasmodium falciparum VAR2CSA Protein
Protein Synonym VAR2; Placental Malaria Protein; CSA-binding PfEMP1; Pn-PfEMP1; VAR2CSA-type PfEMP1

Shipping and Storage

This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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User Note

  1. Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
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