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Recombinant Plasmodium falciparum PfEMP1 Protein, C-His
Product Overview
BioVenic's Recombinant Plasmodium falciparum PfEMP1 Protein, C-His is a recombinant protein expressed from Mammalian Cells. Its predicted molecular weight is 24 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
PfEMP1 is a high-molecular-weight protein family exported by Plasmodium falciparum to the surface of infected red blood cells (iRBCs). Encoded by approximately 60 var genes, it undergoes antigenic variation to evade host immunity. PfEMP1 mediates cytoadherence by binding host receptors such as CD36, ICAM-1, or EPCR, causing iRBCs to sequester in microvasculature. This process prevents splenic clearance and is a primary driver of severe malaria pathology, including cerebral malaria and pregnancy-associated malaria.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.