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Recombinant Mouse Vitamin D3 Receptor (Vdr), N-His
Product Overview
BioVenic's Recombinant Mouse Vitamin D3 Receptor (Vdr), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 21.8 kDa. The purity is>97%.
Specifications
Target Information
Mouse Vitamin D3 Receptor (Vdr) is a nuclear receptor that binds to the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). It plays a critical role in calcium and phosphorus metabolism, bone health, and immune regulation. Vdr is widely expressed in various tissues, including the skeleton, kidneys, intestines, skin, and immune cells. It regulates the expression of genes involved in calcium absorption in the intestines, bone remodeling, and immune responses. In mouse models, Vdr has been studied for its role in preventing and treating diseases such as osteoporosis, autoimmune diseases, and certain cancers. Additionally, Vdr is involved in the regulation of glucose metabolism and has been implicated in the pathogenesis of metabolic disorders like diabetes. Its dysregulation has been linked to various conditions, including bone disorders, immune dysregulation, and metabolic syndrome.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.