Recombinant Mouse Troponin T, Cardiac Muscle (Tnnt2), N-His

Mouse Troponin T, Cardiac Muscle (Tnnt2) is a critical protein in the cardiac muscle sarcomere that plays an essential role in regulating muscle contraction. It is a subunit of the troponin complex, which binds to tropomyosin and helps control the interaction between actin and myosin in response to calcium levels. Tnnt2 is specifically expressed in cardiac muscle and is crucial for normal heart function. Mutations in Tnnt2 are associated with various cardiomyopathies, including hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM), which can lead to heart failure. In mouse models, Tnnt2 deficiency results in severe cardiac dysfunction and early lethality, highlighting its indispensable role in maintaining cardiac contractility and overall heart health.