Recombinant Mouse Superoxide Dismutase [Cu-Zn] (Sod1), N-His

Mouse Superoxide Dismutase [Cu-Zn] (Sod1) is a critical antioxidant enzyme that catalyzes the dismutation of superoxide radicals into oxygen and hydrogen peroxide, protecting cells from oxidative damage. It is predominantly located in the cytoplasm and is essential for maintaining cellular redox balance. In mouse models, Sod1 deficiency leads to increased oxidative stress and susceptibility to various diseases, including neurodegenerative disorders and cancer. Conversely, overexpression of Sod1 can enhance resistance to oxidative stress and extend lifespan. Sod1 is also implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), where mutations in the Sod1 gene can cause familial ALS. Additionally, Sod1 plays a role in inflammatory responses and vascular health, highlighting its importance in both normal physiology and disease.