Recombinant Mouse Proteinase-Activated Receptor 2 (F2rl1), N-His-GST

In mice, Proteinase-Activated Receptor 2 (F2rl1) is a G-protein-coupled receptor involved in various cellular functions such as inflammation, pain sensation, and cancer progression. F2rl1 is activated by proteolytic cleavage of its extracellular amino terminus, which functions as a tethered ligand to activate the receptor. It is involved in the modulation of inflammatory responses and regulation of innate and adaptive immunity. F2rl1 has been implicated in the pathophysiology of various diseases, including cancer, where it can promote tumor growth, invasion, and metastasis. It is also associated with immune evasion in certain cancers. F2rl1 is involved in the regulation of endothelial cell barrier integrity and has a protective role in establishing the endothelial barrier. Additionally, F2rl1 has been studied in the context of pain, where it is expressed by a small population of nociceptors and is involved in mechanical hypersensitivity and spontaneous pain behaviors. Overall, F2rl1 is a multifunctional protein with diverse applications in research, particularly in understanding inflammation, pain, and cancer biology.