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Recombinant Mouse Protein Kinase C Alpha Type (Prkca), N-His
Product Overview
BioVenic's Recombinant Mouse Protein Kinase C Alpha Type (Prkca), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 36.2 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Protein Kinase C Alpha Type (Prkca) is a key serine/threonine kinase involved in calcium-dependent signal transduction. It plays roles in modulating chemical synaptic transmission, regulating bone resorption, and controlling cytokine production involved in inflammation. In mouse models, Prkca is essential for maintaining bone architecture, particularly in females, where it prevents abnormal bone formation in response to mechanical load. Additionally, Prkca is implicated in acute lung injury, where it promotes mitophagy through the miR-15a-5p/PDK4 axis, potentially mitigating sepsis-induced damage. These functions highlight Prkca's importance in various physiological processes and its potential as a therapeutic target.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.