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Recombinant Mouse Protein Jagged-1 (Jag1), N-His
Product Overview
BioVenic's Recombinant Mouse Protein Jagged-1 (Jag1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 32.0 kDa. The purity is> 97%.
Specifications
Target Information
Mouse Protein Jagged-1 (Jag1) is a crucial ligand in the Notch signaling pathway, regulating cell fate decisions and differentiation during development. It is essential for embryonic vascular development and retinal angiogenesis. In tumor biology, Jag1 promotes tumor growth and angiogenesis by activating Notch signaling in endothelial cells, enhancing tumor vascular density and branching. It also supports tumor cell proliferation and epithelial-to-mesenchymal transition (EMT) through Notch3/Hey1 activation. In the inner ear, Jag1 is vital for the formation and maintenance of Hensen's cells and the overall cochlear development. Jag1 dysregulation is linked to diseases like Alagille syndrome, which affects multiple organs, including the liver and inner ear.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.