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Recombinant Mouse Perforin-1 (Prf1), N-His-GST
Product Overview
BioVenic's Recombinant Mouse Perforin-1 (Prf1), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 65.3 kDa. The purity is> 90%.
Specifications
Target Information
Mouse Perforin-1 (Prf1) is a pore-forming protein that plays a crucial role in the cytotoxic activity of immune cells, particularly natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Prf1 forms transmembrane pores in target cells, leading to cell lysis and apoptosis. This process is essential for immune surveillance and the elimination of infected or transformed cells. In mouse models, Prf1 deficiency results in impaired immune responses and increased susceptibility to infections and tumors. Additionally, Prf1 has been implicated in autoimmune diseases, where it can contribute to tissue damage through excessive cytotoxic activity.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.