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Recombinant Mouse Microtubule-Associated Protein Tau (Mapt), N-His
Product Overview
BioVenic's Recombinant Mouse Microtubule-Associated Protein Tau (Mapt), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 36.0 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Microtubule-Associated Protein Tau (Mapt) is essential for stabilizing microtubules in neurons, supporting axonal transport and maintaining neuronal structure. It is encoded by the Mapt gene and exists in multiple isoforms. Tau's function is regulated by its phosphorylation state. Abnormal phosphorylation can lead to its aggregation into neurofibrillary tangles, a hallmark of Alzheimer's disease and other tauopathies. In mouse models, mutations in the Mapt gene cause neurodegenerative changes, highlighting its role in disease. Mapt is also involved in synaptic signaling and DNA repair. Understanding its mechanisms is crucial for developing therapies for neurodegenerative conditions.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.