Recombinant Mouse Microsomal Triglyceride Transfer Protein Large Subunit (Mttp), N-His

Mouse Microsomal Triglyceride Transfer Protein Large Subunit (Mttp) is a critical component of the heterodimeric microsomal triglyceride transfer protein (MTP) complex, which is essential for the assembly and secretion of triglyceride-rich lipoproteins containing apolipoprotein B (apoB). MTP facilitates the transfer of neutral lipids, such as triglycerides and cholesterol esters, from the endoplasmic reticulum (ER) membrane to the forming lipoprotein particles within the ER lumen. This process is crucial for the biosynthesis of very low-density lipoproteins (VLDL) and chylomicrons, which are involved in lipid transport and metabolism. MTP is highly expressed in the liver and intestine, where it plays a vital role in lipid export through apoB-containing lipoproteins. Additionally, MTP is involved in the biosynthesis of CD1 proteins, which are involved in lipid antigen presentation to T cells. In mice, MTP deficiency leads to severe lipid metabolism disorders, including hepatic steatosis and reduced VLDL secretion. MTP is also implicated in the propagation of hepatitis C virus, highlighting its importance in both lipid metabolism and viral pathogenesis.