Recombinant Mouse Laminin Subunit Alpha-1 (Lama1), N-His

Mouse Laminin Subunit Alpha-1 (Lama1) is a crucial component of the laminin family of extracellular matrix proteins. It plays a vital role in various biological processes, including cell adhesion, migration, differentiation, and tissue development. Lama1 is essential for the formation and stability of basement membranes, which are critical for the structural integrity of tissues such as the nervous system, kidneys, and eyes. It interacts with other laminin subunits to form heterotrimers like laminin-111, which are involved in neurite outgrowth and neural tube closure during embryonic development. Additionally, Lama1 is implicated in diseases such as Poretti-Boltshauser syndrome and certain cancers, where its mutations or dysregulation can lead to developmental abnormalities and tissue dysfunction. Recent studies have also explored Lama1 as a therapeutic target in conditions like muscular dystrophy, where increasing its expression could potentially improve muscle function and structure.