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Recombinant Mouse Interleukin-6 Receptor Subunit Alpha (Il6ra)
Product Overview
BioVenic's Recombinant Mouse Interleukin-6 Receptor Subunit Alpha (Il6ra) is a recombinant protein expressed from E.coli. Its predicted molecular weight is 18.0 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Interleukin-6 Receptor Subunit Alpha (Il6ra) is a critical component of the IL-6 receptor complex, enabling IL-6 binding and mediating downstream signaling pathways. It is involved in T-helper 17 cell lineage commitment and plays a key role in immune regulation and inflammation. In the nervous system, Il6ra is implicated in retinal function, with specific knockout studies showing accelerated retinal decline in diabetic mice. Additionally, Il6ra is expressed in various tissues, including the spleen and adipose tissue, and its signaling is associated with metabolic responses and immune dysregulation. In cancer models, Il6ra is involved in tumor progression through the JAK/STAT pathway.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in PBS or others. Aliquot the reconstituted solution to minimize freeze-thaw cycles.