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Recombinant Mouse Insulin-Degrading Enzyme (Ide), N-His
Product Overview
BioVenic's Recombinant Mouse Insulin-Degrading Enzyme (Ide), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 29.7 kDa. The purity is> 90%.
Specifications
Target Information
Mouse Insulin-Degrading Enzyme (IDE) is a zinc metalloprotease that plays a crucial role in regulating insulin levels by degrading insulin, thus influencing glucose homeostasis. IDE is expressed in various tissues, including the brain, pancreas, and liver. In addition to insulin, IDE can degrade other substrates such as glucagon, amylin, and amyloid-beta (Aβ), which are involved in type 2 diabetes and Alzheimer's disease. IDE's activity is regulated by various factors, including ATP and somatostatin, which can modulate its conformation and function. In mouse models, deletion of IDE in pancreatic alpha cells leads to hyperglucagonemia and alpha cell hyperplasia, highlighting its role in glucagon regulation. IDE deficiency also impairs the ability of alpha cells to suppress glucagon release in high glucose conditions, contributing to hyperglucagonemia.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.