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Recombinant Mouse Inositol Polyphosphate-4-Phosphatase Type I A (Inpp4a), N-His
Product Overview
BioVenic's Recombinant Mouse Inositol Polyphosphate-4-Phosphatase Type I A (Inpp4a), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 18.7 kDa. The purity is>95%.
Specifications
Target Information
Mouse Inositol Polyphosphate-4-Phosphatase Type I A (Inpp4a) is a lipid phosphatase that hydrolyzes the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate, playing a role in regulating cell proliferation and apoptosis. It is involved in endocytosis and phagocytosis processes, with studies showing it negatively regulates the phagocytic activity of macrophages by metabolizing phagosomal PtdIns(3,4,5)P3 to PtdIns(3)P. Inpp4a is also implicated in neurodevelopmental disorders, with biallelic truncating variants causing a spectrum of conditions from intellectual disability to pontocerebellar hypoplasia. Additionally, it has been associated with idiopathic pulmonary fibrosis and may serve as a therapeutic target in certain diseases.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.