Recombinant Mouse Glutathione S-Transferase theta-2 (Gstt2)

Mouse Glutathione S-Transferase theta-2 (Gstt2) is a member of the glutathione S-transferase (GST) superfamily, which catalyzes the conjugation of reduced glutathione to various electrophilic and hydrophobic compounds. It plays a crucial role in detoxification processes, protecting cells from oxidative stress and xenobiotics. Gstt2 is involved in the metabolism of endogenous and exogenous compounds, including carcinogens and therapeutic drugs. It has been implicated in cancer progression and drug resistance, with its expression associated with reduced risk in certain cancers like colon cancer and Barrett's esophagus. Gstt2 also modulates immune responses, as seen in its impact on BCG immunotherapy in bladder cancer patients. In mouse models, Gstt2 knockout affects immune cell function and inflammatory responses. Gstt2 is a potential therapeutic target in diseases linked to oxidative stress and cancer.