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Recombinant Mouse Endoplasmin (Hsp90b1), N-His
Product Overview
BioVenic's Recombinant Mouse Endoplasmin (Hsp90b1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 32.0 kDa. The purity is> 90%.
Specifications
Target Information
In mice, Endoplasmin (Hsp90b1) is a crucial molecular chaperone that plays a significant role in protein folding and quality control within the endoplasmic reticulum (ER). It helps in the proper folding of various proteins, including Toll-like receptors, integrin subunits, and the wnt co-receptor low-density lipoprotein receptor-related protein 6 (LRP6), which are linked to immune response and cancer development. Hsp90b1 is also involved in the ER-associated degradation (ERAD) pathway, assisting in the removal of misfolded proteins. Additionally, it has been implicated in cancer progression, with its overexpression observed in several malignancies, suggesting a potential role as a therapeutic target. Hsp90b1's ability to activate anti-tumor immune responses makes it a promising candidate for tumor vaccines.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.