Recombinant Mouse DnaJ Homolog Subfamily A Member 1 (Dnaja1), N-His

In mice, DnaJ Homolog Subfamily A Member 1 (Dnaja1) is a molecular chaperone that assists in protein folding and prevents protein aggregation. It is a member of the DnaJ family, which acts as a cochaperone for heat shock protein 70 (Hsp70) and is involved in various cellular processes, including protein assembly, disassembly, and translocation. Dnaja1 is highly conserved and expressed in a wide range of tissues, including the central nervous system. It plays a role in spermatogenesis, with mice lacking Dnaja1 showing severe defects in this process. Additionally, Dnaja1 is involved in immune responses, specifically in the stabilization of activation-induced deaminase, an enzyme crucial for antibody diversification. In the context of disease, Dnaja1 has been implicated in neurodegenerative conditions, where it helps maintain protein homeostasis and prevent the accumulation of misfolded proteins. Overall, Dnaja1 is a multifunctional protein with diverse applications in research, particularly in understanding protein homeostasis, immune function, and neurodegenerative diseases.