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Recombinant Mouse Dihydrolipoyl Dehydrogenase, Mitochondrial (Dld), N-His-GST
Product Overview
BioVenic's Recombinant Mouse Dihydrolipoyl Dehydrogenase, Mitochondrial (Dld), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 54.0 kDa. The purity is> 80%.
Specifications
Target Information
Mouse Dihydrolipoyl Dehydrogenase, Mitochondrial (Dld) is a key mitochondrial enzyme involved in the oxidative decarboxylation of α-keto acids. It is a component of the pyruvate dehydrogenase complex (PDC), the 2-oxoglutarate dehydrogenase complex (OGDC), and the glycine cleavage system (GCS), playing a crucial role in energy metabolism and amino acid catabolism. Dld catalyzes the transfer of electrons from dihydrolipoamide to NAD+, facilitating the oxidation of α-keto acids to their corresponding acyl-CoA derivatives. In mouse models, Dld is highly expressed in tissues with high metabolic activity, such as the liver and muscle, where it is essential for maintaining cellular energy homeostasis. Abnormal expression or mutations in Dld can lead to metabolic disorders, including lactic acidosis and maple syrup urine disease. Additionally, Dld has been implicated in the regulation of white adipocyte browning by activating mitochondrial function through the RAS/ERK pathway.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.