This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Recombinant Mouse Cyclin-Dependent Kinase Inhibitor 1A Variant 1 (Cdkn1a), N-His
Product Overview
BioVenic's Recombinant Mouse Cyclin-Dependent Kinase Inhibitor 1A Variant 1 (Cdkn1a), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 21.4 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Cyclin-Dependent Kinase Inhibitor 1A Variant 1 (Cdkn1a) is a key regulator of cell cycle progression, primarily functioning to inhibit cyclin-dependent kinases (CDKs) such as CDK2 and CDK4. It plays a crucial role in controlling cell proliferation and maintaining genomic stability by preventing cells from entering the S phase of the cell cycle. Cdkn1a is highly expressed in response to DNA damage and stress signals, acting as a tumor suppressor by halting cell cycle progression and allowing time for DNA repair. In mouse models, Cdkn1a deficiency leads to increased cell proliferation and a higher incidence of tumors.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.