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Recombinant Mouse Complement C4-B (C4b), N-His
Product Overview
BioVenic's Recombinant Mouse Complement C4-B (C4b), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 31.2 kDa. The purity is> 97%.
Specifications
Target Information
Mouse Complement C4-B (C4b) is a key component of the classical pathway of the complement system, which plays a crucial role in the immune response. It is generated from C4 by the action of C1s and forms a complex with C2a to create the C3 convertase, an enzyme that cleaves C3 into C3a and C3b. This process is essential for the activation of the complement cascade, leading to the formation of the membrane attack complex (MAC) and the destruction of pathogens. In mouse models, C4b is highly expressed in the liver and spleen, where it contributes to the clearance of immune complexes and apoptotic cells. Abnormal expression or function of C4b has been implicated in various autoimmune and inflammatory diseases, including systemic lupus erythematosus (SLE) and glomerulonephritis.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.