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Recombinant Mouse Collagen Alpha-1(VI) Chain (Col6a1), N-His
Product Overview
BioVenic's Recombinant Mouse Collagen Alpha-1(VI) Chain (Col6a1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 21.5 kDa. The purity is> 90%.
Specifications
Target Information
Mouse Collagen Alpha-1(VI) Chain (Col6a1) is a critical component of type VI collagen, a flexible protein found in the extracellular matrix (ECM) that provides structural support to cells. It is predominantly expressed in skeletal muscle, connective tissue, and skin. Col6a1 plays a crucial role in maintaining cell stability and growth by linking basement membranes to nearby cells. In mouse models, Col6a1 deficiency leads to severe muscle abnormalities, including muscle weakness, increased apoptosis, and mitochondrial dysfunction. Additionally, Col6a1-null mice exhibit structural abnormalities in the lungs, such as simplified airspaces and increased airway branching. These findings highlight the importance of Col6a1 in tissue development and homeostasis, making it a potential target for therapies addressing collagen VI-related disorders.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.