Recombinant Mouse Coagulation Factor VII (F7)

Mouse Coagulation Factor VII (F7) is a vitamin K-dependent serine protease that plays a pivotal role in initiating the extrinsic pathway of the coagulation cascade. It circulates in the blood as a zymogen and is activated to FVIIa upon tissue injury, in the presence of tissue factor (TF) and calcium ions. Activated FVIIa then catalyzes the conversion of factor X to factor Xa and factor IX to factor IXa, propagating the coagulation cascade, leading to thrombin generation, fibrin deposition, and ultimately clot formation. In mice, F7 deficiency results in severe bleeding disorders, highlighting its essential role in hemostasis. Additionally, F7 is primarily synthesized in the liver and is expressed in various tissues, including the cardiovascular system and hematopoietic system.