Recombinant Mouse Coagulation Factor IX (F9), N-His

In mice, Coagulation Factor IX (F9) is a vitamin K-dependent plasma protein that plays a critical role in the intrinsic blood coagulation pathway. It is synthesized in the liver and circulates as an inactive zymogen, which is activated by factor XIa to form the active form, factor IXa. F9 interacts with calcium ions, membrane phospholipids, and factor VIII to activate factor X, thereby contributing to blood clot formation. F9 deficiency in mice leads to hemophilia B, characterized by prolonged bleeding times and spontaneous bleeding events. F9 KO mouse models are widely used to study hemophilia B and evaluate therapeutic strategies such as gene therapy and inhibitor antibody formation. Additionally, F9 has been implicated in inflammatory bowel disease, where its deficiency provides protection against colitis, suggesting potential roles in immune regulation.