Recombinant Mouse CD27 Antigen (CD27), C-Fc-His

Mouse CD27 Antigen, or CD27, is an antigen expressed on lymphocytes, involved in immune response regulation. In mouse models, CD27 is used to study immune cell development and function. CD27 is a member of the tumor necrosis factor receptor superfamily and interacts with its ligand, CD70, to provide costimulatory signals that are essential for the activation, proliferation, and survival of T and B cells. During lymphocyte development, CD27 expression patterns change, reflecting the differentiation stages of these cells. In the context of immune responses, CD27-CD70 interactions are crucial for the generation of memory T cells and the production of high-affinity antibodies by B cells. Research on CD27 has also explored its potential as a target for immunotherapy, particularly in cancer, where blocking CD27-CD70 signaling may enhance antitumor immune responses. Additionally, CD27 is involved in the pathogenesis of certain autoimmune diseases, where excessive costimulation through this pathway can lead to pathological immune activation. Understanding the multifaceted roles of CD27 in lymphocyte biology and disease has implications for the development of targeted immunomodulatory therapies.