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Recombinant Mouse Broad Substrate Specificity ATP-binding Cassette Transporter ABCG2 (ABCG2), N-His
Product Overview
BioVenic's Recombinant Mouse Broad Substrate Specificity ATP-binding Cassette Transporter ABCG2 (ABCG2), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 34.9 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Broad Substrate Specificity ATP-binding Cassette Transporter ABCG2 (ABCG2) is a key member of the ATP-binding cassette (ABC) transporter family. It functions as an ATP-driven efflux pump, transporting a broad range of substrates, including drugs, toxins, and metabolic byproducts, out of cells. ABCG2 is highly expressed in tissues such as the placenta, liver, intestine, and blood-brain barrier, where it plays a crucial role in protecting cells from xenobiotics and maintaining tissue homeostasis. In cancer, ABCG2 is often overexpressed, contributing to multidrug resistance by expelling chemotherapeutic agents from tumor cells. Additionally, ABCG2 is involved in stem cell maintenance and differentiation, making it a potential marker for cancer stem cells.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.