Recombinant Mouse Beta-Secretase 1 (Bace1), N-His-GST

Mouse Beta-Secretase 1 (Bace1) is a transmembrane aspartyl protease that plays a critical role in the pathogenesis of Alzheimer's disease (AD) by generating amyloid-beta (Aβ) peptides through the cleavage of amyloid precursor protein (APP). Bace1 is the primary β-secretase responsible for the initial step in Aβ production, making it a key target for AD therapy. Inhibiting Bace1 can reduce Aβ levels and potentially slow disease progression. Bace1 is also involved in other physiological processes, such as myelination and synaptic plasticity, and has been implicated in diseases like schizophrenia and epilepsy. Recent studies have highlighted Bace1's role in energy metabolism and homeostasis, suggesting broader therapeutic potential beyond neurodegenerative diseases.