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Recombinant Mouse Angiopoietin-Related Protein 1 (Angptl1), N-His

Cat. No.AP4C365

Product TypeAnimal Proteins

Size

Product Overview

BioVenic's Recombinant Mouse Angiopoietin-Related Protein 1 (Angptl1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 27.3 kDa. The purity is> 97%.

Specifications

Type Recombinant Protein
Species Mouse
Expression System E.coli
Purity > 97%
Endotoxin < 1.0 EU/μg
Predicted Molecular Weight 27.3 kDa
Physical State Lyophilized
Formulation PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

Target Information

In mice, Angiopoietin-Related Protein 1 (Angptl1) is a multifunctional protein involved in angiogenesis, cancer progression, and bone metabolism. Angptl1 is known as a potent anti-angiogenic factor, inhibiting the proliferation and migration of endothelial cells. It also exhibits antiapoptotic activity in human endothelial cells by stimulating the phosphorylation of ERK1/2 and Akt-1. In cancer, Angptl1 expression is down-regulated in several tumor types, including colorectal cancer, where it inhibits epithelial-to-mesenchymal transition (EMT) by suppressing Slug expression, thereby reducing tumor metastasis. Additionally, Angptl1 has been shown to inhibit osteoclast formation and promote osteoblast differentiation, playing a role in bone metabolism. Overall, Angptl1 is a versatile protein with potential applications in cancer therapy and bone-related disorders.

Protein Mouse Angiopoietin-Related Protein 1 (Angptl1)
Protein Synonym Angiopoietin-like protein 1; Angptl1
Gene ID 72713
EC No. Q640P2

Shipping and Storage

This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

User Note

  1. Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.
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