Recombinant Mouse Angiopoietin-2 (ANGPT2), C-Fc

Mouse Angiopoietin-2 (ANGPT2) is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. It is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. ANGPT2 is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel-Palade bodies. Both ANGPT2 and the related Angiopoietin-1 (ANGPT1) are ligands for the receptor tyrosine kinase Tie-2. ANGPT2 is required for postnatal vascular remodeling, and it cooperates with ANGPT1 during lymphatic vessel development. It mediates the up-regulation of ICAM-1 and VCAM-1 on EC, which facilitates the adhesion of leukocytes during inflammation. ANGPT2 is up-regulated in both the endothelium and tumor cells of several cancers as well as in ischemic tissue. Its direct interaction with Integrins promotes tumor cell invasion. ANGPT2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.