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Recombinant Mouse Aggrecan Core Protein (Acan), N-His
Product Overview
BioVenic's Recombinant Mouse Aggrecan Core Protein (Acan), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 13.8 kDa. The purity is> 90%.
Specifications
Target Information
Mouse Aggrecan Core Protein (Acan) is a major component of the cartilage extracellular matrix, crucial for maintaining cartilage structure and function. It is a large proteoglycan that binds to hyaluronic acid (HA) to form large aggregates, providing compressive resistance and maintaining hydration in cartilage. Structurally, Acan consists of three globular regions (G1, G2, G3) connected by extended regions, with the G1 domain being essential for HA interaction. In mouse models, Acan deficiency leads to severe skeletal abnormalities and cartilage degeneration, highlighting its role in skeletal development and maintenance. Additionally, Acan is implicated in diseases like osteoarthritis, where its degradation contributes to cartilage breakdown.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.