Recombinant Mouse 60 kDa Heat Shock Protein, Mitochondrial (Hspd1), N-His

In mice, the 60 kDa Heat Shock Protein, Mitochondrial (Hspd1) is a crucial chaperonin that facilitates the folding and assembly of mitochondrial proteins. It forms a complex with Hsp10, ensuring proper protein function within mitochondria. Hspd1 is involved in various cellular processes, including stress response, immune regulation, and energy metabolism. It plays a role in preventing protein aggregation and maintaining mitochondrial integrity. Research indicates that Hspd1 is essential for embryonic development, as its deficiency leads to early embryonic lethality. In disease models, Hspd1 has been implicated in conditions such as hereditary spastic paraplegia and non-alcoholic fatty liver disease, highlighting its potential as a therapeutic target. Additionally, Hspd1 is involved in cancer progression, where it supports tumor cell survival and metabolic reprogramming. Overall, Hspd1 is a versatile protein with broad applications in studying cellular stress, metabolism, and disease pathology.