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Recombinant Monkeypox Virus Interleukin-18-binding Protein (MPXV D6L), N-His

Cat. No.VG3F85

Product TypeVeterinary Antigens

Size

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Product Overview

BioVenic's Recombinant Monkeypox Virus Interleukin-18-binding Protein (MPXV D6L), N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 16.4 kDa. The purity is>90% (SDS-PAGE).

Specifications

Type Recombinant Protein
Species Virus
Expression System E.coli Expression System
Purity >90% (SDS-PAGE)
Predicted Molecular Weight 16.4 kDa
Physical State Liquid
Formulation 0.01M PBS, pH 7.4.

Target Information

D6L is a secreted virulence factor that functions as a high-affinity decoy receptor for host interleukin-18 (IL-18).1 By mimicking the structure of human IL-18BP, it binds to and neutralizes IL-18 before it can trigger its cognate receptor.2 This action effectively inhibits the production of interferon-gamma (IFN-gamma) and suppresses the activation of NK cells and Th1 lymphocytes. Consequently, D6L plays a vital role in subverting the host's inflammatory response and promoting viral persistence during infection.

Protein Monkeypox Virus Interleukin-18-binding Protein (MPXV D6L)
Protein Synonym D6L; MPXVgp048; vIL-18BP; Interleukin-18 inhibitor; Orthopoxvirus D6L
Gene ID 72551423
UniProt ID A0A7H0DMZ8

Shipping and Storage

This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.

Documents

Datasheet

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

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User Note

  1. Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.
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