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Recombinant Monkeypox Virus F3L Protein (MPXV F3L), N-His
Product Overview
BioVenic's Recombinant Monkeypox Virus F3L Protein (MPXV F3L), N-His is a recombinant protein expressed from E.coli Expression System. Its predicted molecular weight is 18.6 kDa. The purity is>90% (SDS-PAGE).
Specifications
Target Information
F3L is a key immune evasion protein and a homolog of the Vaccinia virus E3L. It contains a conserved C-terminal double-stranded RNA-binding domain (dsRBD) that sequesters viral dsRNA, preventing its detection by host pathogen-sensing receptors like PKR and RIG-I. By disrupting these pathways, F3L effectively inhibits the production of Type I interferons and suppresses host cell apoptosis. This dual-action mechanism allows the virus to circumvent the innate antiviral response, making F3L a primary target for developing small-molecule inhibitors.
Shipping and Storage
This product is shipped with gel ice bags. Avoid repeated freezing and thawing. Store for 12 months at -20°C or -80°C.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Aliquote the reconstituted solution to minimise freeze-thaw cycles.